First trimester alcohol exposure alters placental perfusion and fetal oxygen availability affecting fetal growth and development in a non-human primate model
Background Prenatal alcohol exposure leads to impaired fetal growth, brain development,
and stillbirth. Placental impairment likely contributes to these adverse outcomes, but the
mechanisms and specific vasoactive effects of alcohol that links altered placental function to
impaired fetal development remain areas of active research. Objective Recently, we
developed magnetic resonance imaging techniques in nonhuman primates to characterize
placental blood oxygenation through measurements of T 2* and perfusion using dynamic …
and stillbirth. Placental impairment likely contributes to these adverse outcomes, but the
mechanisms and specific vasoactive effects of alcohol that links altered placental function to
impaired fetal development remain areas of active research. Objective Recently, we
developed magnetic resonance imaging techniques in nonhuman primates to characterize
placental blood oxygenation through measurements of T 2* and perfusion using dynamic …