Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration
A May, F Su, B Dinh, R Ehlen, C Tran… - Experimental Eye …, 2021 - Elsevier
Age-related macular degeneration (AMD) is the most common cause of central vision loss
among elderly populations in industrialized countries. Genome-wide association studies
have consistently associated two genomic loci with progression to late-stage AMD: the
complement factor H (CFH) locus on chromosome 1q31 and the age-related maculopathy
susceptibility 2-HtrA serine peptidase 1 (ARMS2-HTRA1) locus on chromosome 10q26.
While the CFH risk variant has been shown to alter complement activity, the ARMS2-HTRA1 …
among elderly populations in industrialized countries. Genome-wide association studies
have consistently associated two genomic loci with progression to late-stage AMD: the
complement factor H (CFH) locus on chromosome 1q31 and the age-related maculopathy
susceptibility 2-HtrA serine peptidase 1 (ARMS2-HTRA1) locus on chromosome 10q26.
While the CFH risk variant has been shown to alter complement activity, the ARMS2-HTRA1 …
