The effect of aristolochic acid I on expression of NAD (P) H: quinone oxidoreductase in mice and rats—A comparative study
F Bárta, K Levová, E Frei, HH Schmeiser, VM Arlt… - … /Genetic toxicology and …, 2014 - Elsevier
Aristolochic acid is the cause of aristolochic acid nephropathy (AAN) and Balkan endemic
nephropathy (BEN) and their associated urothelial malignancies. Using Western blotting, we
investigated the expression of NAD (P) H: quinone oxidoreductase (NQO1), the most
efficient cytosolic enzyme that reductively activates aristolochic acid I (AAI) in mice and rats.
In addition, the effect of AAI on the expression of the NQO1 protein and its enzymatic activity
in these experimental animal models was examined. We found that NQO1 protein levels in …
nephropathy (BEN) and their associated urothelial malignancies. Using Western blotting, we
investigated the expression of NAD (P) H: quinone oxidoreductase (NQO1), the most
efficient cytosolic enzyme that reductively activates aristolochic acid I (AAI) in mice and rats.
In addition, the effect of AAI on the expression of the NQO1 protein and its enzymatic activity
in these experimental animal models was examined. We found that NQO1 protein levels in …
