Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in
barrier tissues, where they enable efficient frontline defense against infections and cancer.
However, the long-term persistence of these cells has been implicated in a variety of
immune-mediated pathologies. Consequently, modulating TRM cell populations represents
an attractive strategy for novel vaccination and therapeutic interventions against tissue …