[HTML][HTML] T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming
K Dhume, CM Finn, TM Strutt, S Sell, KK McKinstry - Mucosal immunology, 2019 - Elsevier
Although clearance of many intracellular pathogens requires T-bet-dependent CD4 T cell
programming, the extent to which T-bet is needed to direct protective CD4 responses
against influenza is not known. Here, we characterize wild-type and T-bet-deficient CD4
cells during murine influenza infection. Surprisingly, although T-bet expression has broad
impacts on cytokine production by virus-specific CD4 cells, the protective efficacy of T-bet-
deficient effector cells is only marginally reduced. This reduction is due to lower CXCR3 …
programming, the extent to which T-bet is needed to direct protective CD4 responses
against influenza is not known. Here, we characterize wild-type and T-bet-deficient CD4
cells during murine influenza infection. Surprisingly, although T-bet expression has broad
impacts on cytokine production by virus-specific CD4 cells, the protective efficacy of T-bet-
deficient effector cells is only marginally reduced. This reduction is due to lower CXCR3 …
