[HTML][HTML] The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms
TD Randall, RE Mebius - Mucosal immunology, 2014 - Elsevier
Mucosal surfaces are constantly exposed to environmental antigens, colonized by
commensal organisms and used by pathogens as points of entry. As a result, the immune
system has devoted the bulk of its resources to mucosal sites to maintain symbiosis with
commensal organisms, prevent pathogen entry, and avoid unnecessary inflammatory
responses to innocuous antigens. These functions are facilitated by a variety of mucosal
lymphoid organs that develop during embryogenesis in the absence of microbial stimulation …
commensal organisms and used by pathogens as points of entry. As a result, the immune
system has devoted the bulk of its resources to mucosal sites to maintain symbiosis with
commensal organisms, prevent pathogen entry, and avoid unnecessary inflammatory
responses to innocuous antigens. These functions are facilitated by a variety of mucosal
lymphoid organs that develop during embryogenesis in the absence of microbial stimulation …
