Establishment of mixed chimerism through transplantation of allogeneic donor bone marrow
(BM) into sufficiently conditioned recipients is an effective experimental approach for the
induction of transplantation tolerance. Clinical translation, however, is impeded by the lack
of feasible protocols devoid of cytoreductive conditioning (ie irradiation and cytotoxic
drugs/mAbs). The therapeutic application of regulatory T cells (Tregs) prolongs allograft
survival in experimental models, but appears insufficient to induce robust tolerance on its …