WE propose to describe, in its pathologic and clinical details, a disease of the terminal ileum,
affecting mainly young adults, characterized by-a subacute or chronic necrotizing and
cicatrizing inflammation. The ulceration of the mucosa is accompanied by a disproportionate
connective tissue reaction of the remaining walls of the involved intestine, a process which
frequently leads to stenosis of the lumen of the intestine, associated with the formation of
multiple fistulas. The disease is clinically featured by symptoms that resemble those of …