AP-2γ and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3β-hydroxysteroid dehydrogenase VI gene, Hsd3b6
L Peng, AH Payne - Journal of Biological Chemistry, 2002 - jbc.org
The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is essential for the
biosynthesis of all active steroid hormones. It exists as multiple isoforms in humans and
rodents, each the product of a distinct gene. Human 3β-HSD I in placenta is essential for
placental progesterone biosynthesis and thus is essential for the maintenance of pregnancy.
The murine ortholog, 3β-HSD VI, is the only isoform expressed in giant trophoblast cells
during the first half of mouse pregnancy. This study was designed to identify the cis-acting …
biosynthesis of all active steroid hormones. It exists as multiple isoforms in humans and
rodents, each the product of a distinct gene. Human 3β-HSD I in placenta is essential for
placental progesterone biosynthesis and thus is essential for the maintenance of pregnancy.
The murine ortholog, 3β-HSD VI, is the only isoform expressed in giant trophoblast cells
during the first half of mouse pregnancy. This study was designed to identify the cis-acting …
