[HTML][HTML] Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression …
Purpose To evaluate conjunctival cell microRNA (miRNAs) and mRNA expression in
relation to observed phenotype of progressive limbal stem cell deficiency in a cohort of
subjects with congenital aniridia with known genetic status. Methods Using impression
cytology, bulbar conjunctival cells were sampled from 20 subjects with congenital aniridia
and 20 age and sex-matched healthy control subjects. RNA was extracted and miRNA and
mRNA analyses were performed using microarrays. Results were related to severity of …
relation to observed phenotype of progressive limbal stem cell deficiency in a cohort of
subjects with congenital aniridia with known genetic status. Methods Using impression
cytology, bulbar conjunctival cells were sampled from 20 subjects with congenital aniridia
and 20 age and sex-matched healthy control subjects. RNA was extracted and miRNA and
mRNA analyses were performed using microarrays. Results were related to severity of …
