Dysfunction of the limbal epithelial stem cell niche in aniridia-associated keratopathy
U Schlötzer-Schrehardt, L Latta, A Gießl, M Zenkel… - The Ocular Surface, 2021 - Elsevier
Purpose Abnormalities in the limbal niche microenvironment have been suggested to be
causally involved in aniridia-associated keratopathy (AAK), but histological analyses on the
limbal structure and composition in AAK are lacking. Here, we investigated morphologic and
molecular alterations of the limbal epithelial stem cell niche in human congenital aniridia.
Methods The blind, buphthalmic and painful left eye of a 16-year old girl with congenital
aniridia and juvenile glaucoma had to be enucleated because of uncontrolled intraocular …
causally involved in aniridia-associated keratopathy (AAK), but histological analyses on the
limbal structure and composition in AAK are lacking. Here, we investigated morphologic and
molecular alterations of the limbal epithelial stem cell niche in human congenital aniridia.
Methods The blind, buphthalmic and painful left eye of a 16-year old girl with congenital
aniridia and juvenile glaucoma had to be enucleated because of uncontrolled intraocular …