Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy
(AAK). Due to the characteristics of AAK and its bilateral nature, clinical management is
challenging and complicated by the multiple coexisting ocular and systemic morbidities in
aniridia. Although it is primarily assumed that AAK originates from a congenital limbal stem
cell deficiency, in recent years AAK and its pathogenesis has been questioned in the light of …