Genetics of crystallins: cataract and beyond
J Graw - Experimental eye research, 2009 - Elsevier
The crystallins were discovered more than 100 years ago by Mörner (1893. Untersuchungen
der Proteinsubstanzen in den lichtbrechenden Medien des Auges. Z. Physiol. Chem. 18, 61–
106) as the main structural proteins of the vertebrate eye lens. Since that time the major
mammalian crystallins referred to as α-, β-, and γ-crystallins were characterized with respect
to their genetic organization, regulation of their expression pattern and participation in
several diseases. In recent years, more and more crystallins have also been identified …
der Proteinsubstanzen in den lichtbrechenden Medien des Auges. Z. Physiol. Chem. 18, 61–
106) as the main structural proteins of the vertebrate eye lens. Since that time the major
mammalian crystallins referred to as α-, β-, and γ-crystallins were characterized with respect
to their genetic organization, regulation of their expression pattern and participation in
several diseases. In recent years, more and more crystallins have also been identified …
