α-Crystallins in the vertebrate eye lens: Complex oligomers and molecular chaperones
MA Sprague-Piercy, MA Rocha… - Annual review of …, 2021 - annualreviews.org
α-Crystallins are small heat-shock proteins that act as holdase chaperones. In humans, αA-
crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues. α-
Crystallins have a central domain flanked by flexible extensions and form dynamic,
heterogeneous oligomers. Structural models show that both the C-and N-terminal
extensions are important for controlling oligomerization through domain swapping. α-
Crystallin prevents aggregation of damaged β-and γ-crystallins by binding to the client …
crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues. α-
Crystallins have a central domain flanked by flexible extensions and form dynamic,
heterogeneous oligomers. Structural models show that both the C-and N-terminal
extensions are important for controlling oligomerization through domain swapping. α-
Crystallin prevents aggregation of damaged β-and γ-crystallins by binding to the client …
