The small heat shock protein αB-crystallin negatively regulates cytochrome c-and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic …
MC Kamradt, F Chen, VL Cryns - Journal of Biological Chemistry, 2001 - jbc.org
Caspases are universal effectors of apoptosis. The mitochondrial and death receptor
pathways activate distinct apical caspases (caspase-9 and-8, respectively) that converge on
the proteolytic activation of the downstream executioner caspase-3. Caspase-9 and-8
cleave procaspase-3 to produce a p24 processing intermediate (composed of its prodomain
and large subunit), which then undergoes autoproteolytic cleavage to remove the
prodomain from the active protease. Recently, several heat shock proteins have been …
pathways activate distinct apical caspases (caspase-9 and-8, respectively) that converge on
the proteolytic activation of the downstream executioner caspase-3. Caspase-9 and-8
cleave procaspase-3 to produce a p24 processing intermediate (composed of its prodomain
and large subunit), which then undergoes autoproteolytic cleavage to remove the
prodomain from the active protease. Recently, several heat shock proteins have been …
