Vaccination strategies in lymphoproliferative disorders: Failures and successes

A Allegra, S Russo, D Gerace, L Calabro, V Maisano… - Leukemia Research, 2015 - Elsevier
Anti-tumor vaccines in lymphoproliferative disorders hold out the prospect of effective tumor
therapies with minimal side effects. The addition of immunotherapy to old and new
chemotherapy regimens has improved both response rates and disease-free survival,
leading in many cases to an extended overall survival. Ideally, an antigen that is used for
vaccination would be specifically expressed in the tumor; it must have an important, causal
part in the multifactorial process that leads to cancer, and it must be expressed stably even …