Interleukin 24: mechanisms and therapeutic potential of an anti-cancer gene
EL Whitaker, VA Filippov… - Cytokine & growth factor …, 2012 - Elsevier
Interleukin 24 (mda-7/IL-24) has been classified as an anti-cancer gene for its ability to
selectively induce cell death in cancer cells while having little to no effect on normal cells.
Although the exact mechanisms by which IL-24 functions have not been completely
elucidated, several pathways have consistently been identified: endoplasmic reticulum
stress, ceramide-mediated events, and the generation of reactive oxygen species. In
addition to these mechanistic analyses, significant progress has also been reported …
selectively induce cell death in cancer cells while having little to no effect on normal cells.
Although the exact mechanisms by which IL-24 functions have not been completely
elucidated, several pathways have consistently been identified: endoplasmic reticulum
stress, ceramide-mediated events, and the generation of reactive oxygen species. In
addition to these mechanistic analyses, significant progress has also been reported …
