Redirecting macrophage function to sustain their “defender” antitumor activity
SL Tzetzo, SI Abrams - Cancer cell, 2021 - cell.com
SL Tzetzo, SI Abrams
Cancer cell, 2021•cell.comMacrophages are multi-functional innate immune cells that occupy normal or pathologic
tissues, including cancer tissues. The importance of macrophage ontogeny and the
transcriptional networks underlying their functional diversity are underappreciated in
immuno-oncology. Here, we discuss the implications of these fundamental characteristics for
therapeutically reprogramming macrophages to sustain their tumoricidal activities.
tissues, including cancer tissues. The importance of macrophage ontogeny and the
transcriptional networks underlying their functional diversity are underappreciated in
immuno-oncology. Here, we discuss the implications of these fundamental characteristics for
therapeutically reprogramming macrophages to sustain their tumoricidal activities.
Macrophages are multi-functional innate immune cells that occupy normal or pathologic tissues, including cancer tissues. The importance of macrophage ontogeny and the transcriptional networks underlying their functional diversity are underappreciated in immuno-oncology. Here, we discuss the implications of these fundamental characteristics for therapeutically reprogramming macrophages to sustain their tumoricidal activities.
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