Mast cells (MCs) contribute prominently to all allergic diseases, yet are still poorly
understood owing to their exclusive residence in tissues. Recently, the use of RNA-
sequencing, proteomics, and other technological advances have accelerated the acquisition
of new knowledge. This includes an expanded definition of MC heterogeneity and
developmental origins, previously unrecognized functions for MCs, discoveries of genetic
causes of MC-related disorders, the introduction of new therapies for clonal MC disease …