Nerve growth factor enhances antigen and other secretagogue-induced histamine release from rat peritoneal mast cells in the absence of phosphatidylserine
M Tomioka, RH Stead, L Nielsen, MD Coughlin… - Journal of allergy and …, 1988 - Elsevier
The effects of 2.5 S nerve growth factor (NGF) and epidermal growth factor (EGF), isolated
from mouse submaxillary glands, on histamine release from rat peritoneal mast cells (PMCs)
were studied. In the absence of phosphatidylserine, NGF (1 ng/ml to 1 μg/ml) did not cause
histamine release from PMCs isolated from normal rats and those infected with the
nematode Nippostrongylus brasiliensis. However, when PMCs (> 97% pure) were
preincubated with NGF and then challenged with worm antigen (Ag), there was a marked …
from mouse submaxillary glands, on histamine release from rat peritoneal mast cells (PMCs)
were studied. In the absence of phosphatidylserine, NGF (1 ng/ml to 1 μg/ml) did not cause
histamine release from PMCs isolated from normal rats and those infected with the
nematode Nippostrongylus brasiliensis. However, when PMCs (> 97% pure) were
preincubated with NGF and then challenged with worm antigen (Ag), there was a marked …
