Fibrodysplasia ossificans progressiva (FOP) is a catastrophic genetic disorder of
progressive heterotopic ossification associated with dysregulated production of bone
morphogenetic protein 4 (BMP4), a potent osteogenic morphogen. Postnatal heterotopic
ossification in FOP is often heralded by hectic episodes of severe post-traumatic connective
tissue swelling and intramuscular edema, followed by an intense and highly angiogenic
fibroproliferative mass. The abrupt appearance, intense size, and rapid intrafascial spread of …