Intrinsic differences between oral and skin keratinocytes
PloS one, 2014•journals.plos.org
Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue
and the behavior of the keratinocytes from these two sites are different. One significant
dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster
and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral
and skin keratinocytes might have intrinsic differences at baseline as well as in the response
to injury, and that such differences would be reflected in gene expression profiles.
and the behavior of the keratinocytes from these two sites are different. One significant
dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster
and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral
and skin keratinocytes might have intrinsic differences at baseline as well as in the response
to injury, and that such differences would be reflected in gene expression profiles.
Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral and skin keratinocytes might have intrinsic differences at baseline as well as in the response to injury, and that such differences would be reflected in gene expression profiles.
PLOS