Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children
SA Lewis, A Sutherland, F Soldevila… - Journal of Allergy and …, 2023 - Elsevier
Background Cow milk (CM) allergy is the most prevalent food allergy in young children in
the United States and Great Britain. Current diagnostic tests are either unreliable (IgE test
and skin prick test) or resource-intensive with risks (food challenges). Objective We sought
to determine whether allergen-specific T cells in CM-allergic (CMA) patients have a distinct
quality and/or quantity that could potentially be used as a diagnostic marker. Methods Using
PBMCs from 147 food-allergic pediatric subjects, we mapped T-cell responses to a set of …
the United States and Great Britain. Current diagnostic tests are either unreliable (IgE test
and skin prick test) or resource-intensive with risks (food challenges). Objective We sought
to determine whether allergen-specific T cells in CM-allergic (CMA) patients have a distinct
quality and/or quantity that could potentially be used as a diagnostic marker. Methods Using
PBMCs from 147 food-allergic pediatric subjects, we mapped T-cell responses to a set of …