Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in
patients with food allergy completing clinical trials and, in some studies, sustained
unresponsiveness. These clinical outcomes have been associated with characteristic
modifications in the allergen-specific immune response, but a detailed synthesis of OIT's
mechanisms of action is lacking. In this rostrum we review the current evidence regarding
the human immune response to OIT, explore possible mechanisms, and identify knowledge …