[HTML][HTML] Ribozyme ablation demonstrates that the cardiac subtype of the voltage-sensitive calcium channel is the molecular transducer of 1, 25-dihydroxyvitamin D3 …

R Liu, W Li, NJ Karin, JJ Bergh, K Adler-Storthz… - Journal of Biological …, 2000 - ASBMB
1, 25-Dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) stimulates transmembrane influx of Ca 2+
through L-type voltage-sensitive Ca 2+ channels (VSCCs) in ROS 17/2.8 osteoblastic cells.
Ca 2+ influx modulates osteoblastic activities including matrix deposition, hormone
responsiveness, and Ca 2+-dependent signaling. 1, 25 (OH) 2 D 3 also regulates transcript
levels encoding VSCCs. L-type VSCCs are multisubunit complexes composed of a central
pore-forming α 1 subunit and four additional subunits. The α 1 subunit is encoded by one …