Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3′→ 5′ exonucleases
DJ Mazur, FW Perrino - Journal of Biological Chemistry, 1999 - jbc.org
The 3′→ 5′ exonucleases catalyze the excision of nucleoside monophosphates from the
3′ termini of DNA. We have identified the cDNA sequences encoding two 3′→ 5′
exonucleases (TREX1 and TREX2) from mammalian cells. The TREX1 and TREX2 proteins
are 304 and 236 amino acids in length, respectively. Analysis of the TREX1 and TREX2
sequences identifies three conserved motifs that likely generate the exonuclease active site
in these enzymes. The specific amino acids in these three conserved motifs suggest that …
3′ termini of DNA. We have identified the cDNA sequences encoding two 3′→ 5′
exonucleases (TREX1 and TREX2) from mammalian cells. The TREX1 and TREX2 proteins
are 304 and 236 amino acids in length, respectively. Analysis of the TREX1 and TREX2
sequences identifies three conserved motifs that likely generate the exonuclease active site
in these enzymes. The specific amino acids in these three conserved motifs suggest that …
