Stromal PD-1+ tumor-associated macrophages predict poor prognosis in lung adenocarcinoma
L Chen, MF Cao, JF Xiao, QH Ma, H Zhang, RL Cai… - Human Pathology, 2020 - Elsevier
Immunotherapies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand (PD-L1)
axis have been emerging as a promising therapeutic strategy to treat lung cancer. PD-1 is
preferentially expressed by activated T lymphocytes; but whether/how its expression by
tumor-associated macrophages (TAMs) in lung adenocarcinoma remains elusive. Herein,
we investigate the frequency of PD-1 expression on TAMs in mouse allografts by flow
cytometry analysis and evaluate the spatial distribution and clinicopathological significance …
axis have been emerging as a promising therapeutic strategy to treat lung cancer. PD-1 is
preferentially expressed by activated T lymphocytes; but whether/how its expression by
tumor-associated macrophages (TAMs) in lung adenocarcinoma remains elusive. Herein,
we investigate the frequency of PD-1 expression on TAMs in mouse allografts by flow
cytometry analysis and evaluate the spatial distribution and clinicopathological significance …
