▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors
stimulate proliferation, differentiation, and survival signals, as well as specialized functions
in host resistance to pathogens. Although cytokines are known to activate multiple signaling
pathways that together mediate these important functions, one of these pathways, the Jak-
STAT pathway, is the focus of this chapter. This pathway is triggered by both cytokines and …