Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity
Y Kanno, G Vahedi, K Hirahara… - Annual review of …, 2012 - annualreviews.org
T helper cell differentiation occurs in the context of the extracellular cytokine milieu evoked
by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The
culmination of these signals results in specification of T helper lineages, which occurs
through the combinatorial action of multiple transcription factors that establish distinctive
transcriptomes. In this manner, inducible, but constitutively active, master regulators work in
conjunction with factors such as the signal transducer and activator of transcriptions (STATs) …
by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The
culmination of these signals results in specification of T helper lineages, which occurs
through the combinatorial action of multiple transcription factors that establish distinctive
transcriptomes. In this manner, inducible, but constitutively active, master regulators work in
conjunction with factors such as the signal transducer and activator of transcriptions (STATs) …
