Oncoprotein v-Myb and retinoic acid receptor α are mutual antagonists
K Zemanová, J Šmarda - Blood Cells, Molecules, and Diseases, 1998 - Elsevier
The process of hematopoiesis is critically dependent on correct interactions of multiple
regulatory molecules and transcription factors. We have studied the interactions of the v-Myb
and retinoic acid receptor proteins which have opposing effects on hematopoiesis. While v-
mybacts as a transforming oncogene preventing differentiation of monoblasts to
macrophages, RARα functions as an anti-oncogene arresting the growth of v-myb-
transformed cells and allowing their final myeloid differentiation steps to occur. We found …
regulatory molecules and transcription factors. We have studied the interactions of the v-Myb
and retinoic acid receptor proteins which have opposing effects on hematopoiesis. While v-
mybacts as a transforming oncogene preventing differentiation of monoblasts to
macrophages, RARα functions as an anti-oncogene arresting the growth of v-myb-
transformed cells and allowing their final myeloid differentiation steps to occur. We found …
