Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
AF Leithner, J Renkawitz, I De Vries… - European journal …, 2018 - research-explorer.ista.ac.at
European journal of immunology, 2018•research-explorer.ista.ac.at
Dendritic cells (DCs) are sentinels of the adaptive immune system that reside in peripheral
organs of mammals. Upon pathogen encounter, they undergo maturation and up-regulate
the chemokine receptor CCR7 that guides them along gradients of its chemokine ligands
CCL19 and 21 to the next draining lymph node. There, DCs present peripherally acquired
antigen to naïve T cells, thereby triggering adaptive immunity.
organs of mammals. Upon pathogen encounter, they undergo maturation and up-regulate
the chemokine receptor CCR7 that guides them along gradients of its chemokine ligands
CCL19 and 21 to the next draining lymph node. There, DCs present peripherally acquired
antigen to naïve T cells, thereby triggering adaptive immunity.
Abstract
Dendritic cells (DCs) are sentinels of the adaptive immune system that reside in peripheral organs of mammals. Upon pathogen encounter, they undergo maturation and up-regulate the chemokine receptor CCR7 that guides them along gradients of its chemokine ligands CCL19 and 21 to the next draining lymph node. There, DCs present peripherally acquired antigen to naïve T cells, thereby triggering adaptive immunity.
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