Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
A Feliciello, I Ciullo, GF Fenzi, G Bonavolonta… - The Lancet, 1993 - Elsevier
A Feliciello, I Ciullo, GF Fenzi, G Bonavolonta, A Porcellini, EV Avvedimento
The Lancet, 1993•ElsevierIt is not clear wether the ophtalmopathy present in Graves' disease is related to autoimmune
reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated
to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can
stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found.
We have shown, by polymerase chain reaction amplification of specific cDNA, that mature
TSH-R mRNA is expressed in the retro-orbital tissue of both healthy subjects and patients …
reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated
to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can
stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found.
We have shown, by polymerase chain reaction amplification of specific cDNA, that mature
TSH-R mRNA is expressed in the retro-orbital tissue of both healthy subjects and patients …
Abstract
It is not clear wether the ophtalmopathy present in Graves' disease is related to autoimmune reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found. We have shown, by polymerase chain reaction amplification of specific cDNA, that mature TSH-R mRNA is expressed in the retro-orbital tissue of both healthy subjects and patients with Graves' disease. Of other tissues and cells tested (fibroblasts, lymphocytes, muscle, and thyroid), only thyroid tissue expressed the TSH-R mRNA. Lancet 1993; 342: 337–38
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