Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy
TJ Smith, L Hegedüs, RS Douglas - Best practice & research Clinical …, 2012 - Elsevier
The etiology of Graves' orbitopathy (GO) remains enigmatic and thus controversy surrounds
its pathogenesis. The role of the thyroid stimulating hormone receptor (TSHR) and activating
antibodies directed against it in the hyperthyroidism of Graves' disease (GD) is firmly
established. Less well elucidated is what part the TSHR pathway might play in the
development of GO. Also uncertain is the participation of other cell surface receptors in the
disease. Elevated levels of insulin-like growth factor-1 receptor (IGF-1R) have been found in …
its pathogenesis. The role of the thyroid stimulating hormone receptor (TSHR) and activating
antibodies directed against it in the hyperthyroidism of Graves' disease (GD) is firmly
established. Less well elucidated is what part the TSHR pathway might play in the
development of GO. Also uncertain is the participation of other cell surface receptors in the
disease. Elevated levels of insulin-like growth factor-1 receptor (IGF-1R) have been found in …
