Insulin-like growth factor-1 enhances the expression of functional TSH receptor in orbital fibroblasts from thyroid-associated ophthalmopathy
JS Paik, SE Kim, JH Kim, JY Lee, SW Yang, SB Lee - Immunobiology, 2020 - Elsevier
Abstract Thyroid-associated ophthalmopathy (TAO), an autoimmune disease, occurs in
approximately 50% of patients with Graves' hyperthyroidism. Thyroid-stimulating hormone
receptor (TSHR) that is expressed in orbital fibroblasts is the autoimmune target in the
development of TAO. In addition to thyroid-stimulating immunoglobulin (TSI), insulin-like
growth factor (IGF)-1 is also involved in the development of TAO. IGF-1 has been reported to
potentiate the effects of thyroid-stimulating hormone (TSH) and TSI on TSHR signaling. In …
approximately 50% of patients with Graves' hyperthyroidism. Thyroid-stimulating hormone
receptor (TSHR) that is expressed in orbital fibroblasts is the autoimmune target in the
development of TAO. In addition to thyroid-stimulating immunoglobulin (TSI), insulin-like
growth factor (IGF)-1 is also involved in the development of TAO. IGF-1 has been reported to
potentiate the effects of thyroid-stimulating hormone (TSH) and TSI on TSHR signaling. In …
