Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid
S Ragheb, Y Li, K Simon… - Multiple Sclerosis …, 2011 - journals.sagepub.com
S Ragheb, Y Li, K Simon, S VanHaerents, D Galimberti, M De Riz, C Fenoglio, E Scarpini…
Multiple Sclerosis Journal, 2011•journals.sagepub.comBackground: There is increasing evidence of B-cell involvement in the pathogenesis of
multiple sclerosis (MS). B-cell activating factor (BAFF) has an essential role in B-cell
homeostasis. The chemokine CXCL13 has an important role in the formation and
maintenance of B-cell follicles. Objective: To measure BAFF and CXCL13 levels in the
cerebrospinal fluid (CSF) of patients with MS compared to patients with other neurological
diseases. Methods: Cytokine/chemokine levels were measured by an enzyme-linked …
multiple sclerosis (MS). B-cell activating factor (BAFF) has an essential role in B-cell
homeostasis. The chemokine CXCL13 has an important role in the formation and
maintenance of B-cell follicles. Objective: To measure BAFF and CXCL13 levels in the
cerebrospinal fluid (CSF) of patients with MS compared to patients with other neurological
diseases. Methods: Cytokine/chemokine levels were measured by an enzyme-linked …
Background: There is increasing evidence of B-cell involvement in the pathogenesis of multiple sclerosis (MS). B-cell activating factor (BAFF) has an essential role in B-cell homeostasis. The chemokine CXCL13 has an important role in the formation and maintenance of B-cell follicles.
Objective: To measure BAFF and CXCL13 levels in the cerebrospinal fluid (CSF) of patients with MS compared to patients with other neurological diseases.
Methods: Cytokine/chemokine levels were measured by an enzyme-linked immunosorbent assay (ELISA).
Results: In MS patients, BAFF levels were highest in patients with secondary progressive disease, and were higher during relapse in patients with relapsing–remitting and secondary progressive disease. CXCL13 levels were also higher during relapse. There was a positive correlation between CXCL13 and the IgG index, and an inverse correlation between BAFF and the IgG index. The implications of this finding are discussed.
Conclusion: During relapse, we found various positive correlations between BAFF, CXCL13 and the cytokines IL-6 and IL-10. These findings show that molecules that are essential for B-cell recruitment, survival, maturation and function may be working in concert to affect B-cell homeostasis in MS and contribute to the pathophysiology of the disease.
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