Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts
KM Winges, DH Gilden, JL Bennett, X Yu… - Journal of …, 2007 - Elsevier
Fluorescence-activated cell sorting (FACS) analysis of B cell subtypes in 17 CSF samples
from 15 patients with clinically-definite MS revealed that CD19+ B cells accounted for 2 to
11%(mean 5%) and CD138+ cells constituted 0 to 5%(mean 2%) of total CSF lymphocytes.
Further stratification of CD138+ cells based on expression levels of CD19 showed that
CD138+ 19+ plasma blasts constituted 89±2%(mean±SE) of the CD138+ cell population
(P< 0.00001), with more mature plasma cells (CD138+ 19−) constituting the remaining …
from 15 patients with clinically-definite MS revealed that CD19+ B cells accounted for 2 to
11%(mean 5%) and CD138+ cells constituted 0 to 5%(mean 2%) of total CSF lymphocytes.
Further stratification of CD138+ cells based on expression levels of CD19 showed that
CD138+ 19+ plasma blasts constituted 89±2%(mean±SE) of the CD138+ cell population
(P< 0.00001), with more mature plasma cells (CD138+ 19−) constituting the remaining …