Hepatocellular ballooning in NASH
S Caldwell, Y Ikura, D Dias, K Isomoto, A Yabu… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Hepatocellular ballooning is a key finding in nonalcoholic
steatohepatitis (NASH). It is conventionally defined by hemotoxylin and eosin (H&E) staining
showing enlarged cells with rarefied cytoplasm and recently by changes in the cytoskeleton.
Fat droplets are emerging as important organelles in cell metabolism. To address a possible
relation between fat droplets and ballooning, we studied fat staining, H&E, and keratin 18
staining in human NASH. METHODS: Sequential staining and high resolution imaging were …
steatohepatitis (NASH). It is conventionally defined by hemotoxylin and eosin (H&E) staining
showing enlarged cells with rarefied cytoplasm and recently by changes in the cytoskeleton.
Fat droplets are emerging as important organelles in cell metabolism. To address a possible
relation between fat droplets and ballooning, we studied fat staining, H&E, and keratin 18
staining in human NASH. METHODS: Sequential staining and high resolution imaging were …