[HTML][HTML] EMT: when epithelial cells decide to become mesenchymal-like cells

R Kalluri - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
The Journal of clinical investigation, 2009Am Soc Clin Investig
Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development,
and this process is re-engaged in adults during wound healing, tissue regeneration, organ
fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of
EMT in adults but is absent during embryonic development. As highlighted in this Review
series, EMT is now a recognized mechanism for dispersing cells in embryos, forming
fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial …
Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.
The Journal of Clinical Investigation