Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation
RN Helsley, SH Park, HJ Vekaria, PG Sullivan… - Journal of …, 2023 - Elsevier
Background & Aims The consumption of sugar and a high-fat diet (HFD) promotes the
development of obesity and metabolic dysfunction. Despite their well-known synergy, the
mechanisms by which sugar worsens the outcomes associated with a HFD are largely
elusive. Methods Six-week-old, male, C57Bl/6 J mice were fed either chow or a HFD and
were provided with regular, fructose-or glucose-sweetened water. Moreover, cultured
AML12 hepatocytes were engineered to overexpress ketohexokinase-C (KHK–C) using a …
development of obesity and metabolic dysfunction. Despite their well-known synergy, the
mechanisms by which sugar worsens the outcomes associated with a HFD are largely
elusive. Methods Six-week-old, male, C57Bl/6 J mice were fed either chow or a HFD and
were provided with regular, fructose-or glucose-sweetened water. Moreover, cultured
AML12 hepatocytes were engineered to overexpress ketohexokinase-C (KHK–C) using a …
