GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors
C Ørskov, B Hartmann, SS Poulsen, J Thulesen… - Regulatory peptides, 2005 - Elsevier
BACKGROUND: Glucagon-like peptide-2 is thought to act as a growth factor for the gut, but
the localization of the GLP-2 receptor and mechanism of action on epithelial growth is
unclear. METHODS AND RESULTS: We found glucagon–like peptide-2 (GLP-2) receptors
mainly on subepithelial myofibroblasts in rat, mouse, marmoset and human small and large
intestine by immunohistochemistry and in situ hybridisation. By double labelling we found
that these GLP-2 receptor immunoreactive cells also produce smooth muscle actin and …
the localization of the GLP-2 receptor and mechanism of action on epithelial growth is
unclear. METHODS AND RESULTS: We found glucagon–like peptide-2 (GLP-2) receptors
mainly on subepithelial myofibroblasts in rat, mouse, marmoset and human small and large
intestine by immunohistochemistry and in situ hybridisation. By double labelling we found
that these GLP-2 receptor immunoreactive cells also produce smooth muscle actin and …