The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine

J Pedersen, NB Pedersen, SW Brix, KV Grunddal… - Peptides, 2015 - Elsevier
Abstract Glucagon-like peptide 2 (GLP-2) is a potent intestinotrophic growth factor with
therapeutic potential in the treatment of intestinal deficiencies. It has recently been approved
for the treatment of short bowel syndrome. The effects of GLP-2 are mediated by specific
binding of the hormone to the GLP-2 receptor (GLP-2R) which was cloned in 1999.
However, consensus about the exact receptor localization in the intestine has never been
established. By physical, chemical and enzymatic tissue fragmentation, we were able to …