Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms
L Capuron, S Schroecksnadel, C Féart, A Aubert… - Biological …, 2011 - Elsevier
BACKGROUND: Neuropsychiatric symptoms are common complaints of elderly persons.
Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of
aging, plays a role. Effects might rely on the influence of inflammation on the activity of two
enzymatic pathways, the indoleamine-2, 3-dioxygenase (IDO) and the guanosine-
triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis
of monoamines. The present study assessed this possibility in 284 healthy elderly subjects …
Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of
aging, plays a role. Effects might rely on the influence of inflammation on the activity of two
enzymatic pathways, the indoleamine-2, 3-dioxygenase (IDO) and the guanosine-
triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis
of monoamines. The present study assessed this possibility in 284 healthy elderly subjects …
