Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens

D Orange, M Frank, S Tian, A Dousmanis… - Archives of …, 2012 - jamanetwork.com
Background Tumor treatment is the mainstay of therapy for paraneoplastic neurologic
disorders (PNDs), but it is only effective in some cases and other treatment options are
limited. Objective To evaluate the short-term use of a combination of prednisone and
tacrolimus for acute neurologic worsening in PND in which intracellular antigens are
targeted. Design Retrospective single-center case series of patients with PND treated with
tacrolimus. Setting The Rockefeller University Hospital, a research hospital in New York …