Nonstructured treatment interruptions are associated with higher human immunodeficiency virus reservoir size measured by intact proviral DNA assay in people who …
The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in CD4+ T cells is a
major barrier to cure. HIV-1–infected persons who inject drugs (PWID) often struggle to
maintain suppression of viremia and experience nonstructured treatment interruptions
(NTIs). The effects of injecting drugs or NTIs on the reservoir are unclear. Using the intact
proviral DNA assay, we found no apparent effect of heroin or cocaine use on reservoir size.
However, we found significantly larger reservoirs in those with frequent NTIs or a shorter …
major barrier to cure. HIV-1–infected persons who inject drugs (PWID) often struggle to
maintain suppression of viremia and experience nonstructured treatment interruptions
(NTIs). The effects of injecting drugs or NTIs on the reservoir are unclear. Using the intact
proviral DNA assay, we found no apparent effect of heroin or cocaine use on reservoir size.
However, we found significantly larger reservoirs in those with frequent NTIs or a shorter …
[PDF][PDF] Non-structured treatment interruptions are associated with higher HIV reservoir size measured by intact proviral DNA assay in people who inject drugs
Accepted Manuscript Page 1 Accepted Manuscript © The Author(s) 2020. Published by Oxford
University Press for the Infectious Diseases Society of America. All rights reserved. For
permissions, e-mail: journals.permissions@oup.com. Non-structured treatment interruptions
are associated with higher HIV reservoir size measured by intact proviral DNA assay in people
who inject drugs Gregory D. Kirk1,2, Jacqueline Astemborski1, Shruti H. Mehta1, Kristen D.
Ritter3, Gregory M. Laird3, Rebeka Bordi4, Rafick Sekaly4, Janet D. Siliciano2, and Robert F …
University Press for the Infectious Diseases Society of America. All rights reserved. For
permissions, e-mail: journals.permissions@oup.com. Non-structured treatment interruptions
are associated with higher HIV reservoir size measured by intact proviral DNA assay in people
who inject drugs Gregory D. Kirk1,2, Jacqueline Astemborski1, Shruti H. Mehta1, Kristen D.
Ritter3, Gregory M. Laird3, Rebeka Bordi4, Rafick Sekaly4, Janet D. Siliciano2, and Robert F …
