T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional μ-opioid receptors
C Börner, J Kraus, A Bedini, B Schraven, V Höllt - Molecular pharmacology, 2008 - Elsevier
Opiates function as immunomodulators, partly by their effects on T cells. Opioids act via μ-, δ-
, and κ-opioid receptors, among which the μ-type is of particular interest, because morphine-
like opioids preferentially bind to it. Here we report that μ-opioid receptor mRNA was
induced after CD3/28-mediated activation of primary human T lymphocytes and Jurkat T
cells, neither of which expresses the gene constitutively. Moreover, a reporter gene construct
containing 2624 base pairs of the μ-opioid receptor promoter was transactivated by CD3/28 …
, and κ-opioid receptors, among which the μ-type is of particular interest, because morphine-
like opioids preferentially bind to it. Here we report that μ-opioid receptor mRNA was
induced after CD3/28-mediated activation of primary human T lymphocytes and Jurkat T
cells, neither of which expresses the gene constitutively. Moreover, a reporter gene construct
containing 2624 base pairs of the μ-opioid receptor promoter was transactivated by CD3/28 …
