Quantification of cardiolipin by liquid chromatography‐electrospray ionization mass spectrometry
TA Garrett, R Kordestani, CRH Raetz - Methods in Enzymology, 2007 - Elsevier
Abstract Cardiolipin (CL), a tetra‐acylated glycerophospholipid composed of two
phosphatidyl moieties linked by a bridging glycerol, plays an important role in mitochondrial
function in eukaryotic cells. Alterations to the content and acylation state of CL cause
mitochondrial dysfunction and may be associated with pathologies such as ischemia,
hypothyrodism, aging, and heart failure. The structure of CL is very complex because of
microheterogeneity among its four acyl chains. Here we have developed a method for the …
phosphatidyl moieties linked by a bridging glycerol, plays an important role in mitochondrial
function in eukaryotic cells. Alterations to the content and acylation state of CL cause
mitochondrial dysfunction and may be associated with pathologies such as ischemia,
hypothyrodism, aging, and heart failure. The structure of CL is very complex because of
microheterogeneity among its four acyl chains. Here we have developed a method for the …