Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor
Y Shiraishi, K Asano, T Nakajima, T Oguma… - The Journal of …, 2005 - Elsevier
Mast cell-derived prostaglandin D 2 (PGD 2) is one of the essential modulators of
eosinophilic airway inflammation in asthma and allergic rhinitis. Two G protein-coupled
receptors for PGD 2, prostaglandin D 2 receptor (DP) and chemoattractant receptor-
homologous molecule expressed on Th 2 cells (CRTH2), are both expressed on the surface
of eosinophils, and CRTH2 has been demonstrated to mediate PGD 2-induced eosinophil
mobilization in vitro. However, it has not yet been determined whether PGD 2 and its …
eosinophilic airway inflammation in asthma and allergic rhinitis. Two G protein-coupled
receptors for PGD 2, prostaglandin D 2 receptor (DP) and chemoattractant receptor-
homologous molecule expressed on Th 2 cells (CRTH2), are both expressed on the surface
of eosinophils, and CRTH2 has been demonstrated to mediate PGD 2-induced eosinophil
mobilization in vitro. However, it has not yet been determined whether PGD 2 and its …