Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury
CG Lee, CA Da Silva, CS Dela Cruz… - Annual review of …, 2011 - annualreviews.org
The 18 glycosyl hydrolase family of chitinases is an ancient gene family that is widely
expressed from prokaryotes to eukaryotes. In mammals, despite the absence of endogenous
chitin, a number of chitinases and chitinase-like proteins (C/CLPs) have been identified.
However, their roles have only recently begun to be elucidated. Acidic mammalian chitinase
(AMCase) inhibits chitin-induced innate inflammation; augments chitin-free, allergen-
induced Th2 inflammation; and mediates effector functions of IL-13. The CLPs BRP-39/YKL …
expressed from prokaryotes to eukaryotes. In mammals, despite the absence of endogenous
chitin, a number of chitinases and chitinase-like proteins (C/CLPs) have been identified.
However, their roles have only recently begun to be elucidated. Acidic mammalian chitinase
(AMCase) inhibits chitin-induced innate inflammation; augments chitin-free, allergen-
induced Th2 inflammation; and mediates effector functions of IL-13. The CLPs BRP-39/YKL …
