Integration of gene-expression profiles and pathway analysis in ascending thoracic aortic aneurysms

JH Kim, CY Na, SY Choi, HW Kim, Y Du Kim… - Annals of Vascular …, 2010 - Elsevier
BACKGROUND: Despite the increasing incidence of ascending thoracic aortic aneurysms,
their pathogenesis and molecular mechanisms remain unknown. The aim of this study was
to identify the biological pathways of genes that are expressed differentially in ascending
aortic aneurysms. METHODS: Aneurysm wall tissues were obtained from thoracic aortic
aneurysms during their repair and normal thoracic aortas from organ transplant patients. The
differential expression of genes was analyzed by NimbleGen microarrays. The biological …