Despite major advances in understanding the mechanisms leading to tumor immunity, a
number of obstacles hinder the successful translation of mechanistic insights into effective
tumor immunotherapy. Such obstacles include the ability of tumors to foster a tolerant
microenvironment and the activation of a plethora of immunosuppressive mechanisms,
which may act in concert to counteract effective immune responses. Here we discuss
different strategies employed by tumors to thwart immune responses, including tumor …